Carlo Santagata

On Newton's paradoxes

Reading the Principia [1] it is easy to realize that Newton, without being aware of the fact, has corrected the law of the fall of bodies formulated by Galilei. In the present paper we examine the consequences of such a fact and show that they affect the entire Celestial Mechanics, being related to the very small 43” per century of the perihelion shift of Mercury as well as to the substantial 5...

Recombinase Complex Within the Recombination - Activating Genes Definition of Minimal Domains of Interaction

The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy

Stromal cells within the tumor microenvironment are essential for tumor progression and metastasis. Surprisingly little is known about the factors that drive the transcriptional reprogramming of stromal cells within tumors. We report that the transcriptional regulator heat shock factor 1 (HSF1) is frequently activated in cancer-associated fibroblasts (CAFs), where it is a potent enabler of mali...

Mutations for the people

Similar cancer types may nevertheless differ widely in the genetic mutations they carry. In this Closeup, Kristensen and Borresen-Dale discuss how identifying these mutations can define which therapy is most likely to succeed in eliminating the cancerous cells and how the methodology developed by Dias-Santagata et al and described in this issue, is an important step in making mutation screening...

Semantic Web in the Automotive Industry: a case study

This paper describes an ongoing case study on management of engineering data to evaluate the use of Semantic Web technologies in automotive industry. This case study explores specifically the theme of data modeling, navigation and retrieval using Semantic Web, data presentation in html+svg and data analysis using neural networks. It implements a web crawler to automatically collect data of inte...